Sildenafil (Revatio)

(Revatio)

Dosage

20 à 80 mg /day in 3 divided doses.

Contra-indications

  • Hypersensitivity to the active substance or to any of the excipients.
  • Potentiation of the hypotensive effects of nitrates, sildenafil was highlighted. This is why its administration to patients using a drug releasing nitric oxide (eg molsidomine, another coronary vasodilator with nitro-compound or nitrates, whatever it is) is absolutely contraindicated indicated.
  • Severe limitation of liver function (ie class C according to Child-Pugh).
  • A history of recent stroke or myocardial infarction.
  • Severe hypotension (blood pressure <90/50 mmHg) at initiation of treatment.
  • Contraindicated when used in combination with the most potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir) (see "Interactions").

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