Pulmonary hypertension (PH)

Diagnosis and treatment

  1. Definitions
  2. Etiology
  3. Symptoms
  4. Algorithm
  5. Treatment
  6. Scores and calculation
  7. Pharmaceuticals
  8. ESC recommandations

Pharmaceuticals

  1. Bosentan (Tracleer)
  2. Nifedipine (Adalat)
  3. Ambrisentan (Volibris)
  4. Amlodipine (Norvasc)
  5. Diltiazem (Dilzem)
  6. Macicentan (Opsumit)
  7. Sildenafil (Revatio)
  8. Tadalafil (Cialis)
  9. Adempas (Riociguat)
  10. Epoprostenol (Flolan ou Velvetri)
  11. Trepostinil (Remodulin)
  12. Vardenafil (Levitra)
  13. Iloprost (Ilomedin)

Bosentan (Tracleer)

(Tracleer)

Dosage

62,5 mg x 2 /day ou 125 mg x 2 /day

Contra-indications

  • Hypersensitivity to bosentan or any of the excipients.
  • Hepatic impairment moderate to severe (Class B or C Child-Pugh see section.
  • Baseline values of liver aminotransferases, aspartate aminotransferase (AST) and / or alanine aminotransferase (ALT) levels greater than 3 times the upper limit of normal before treatment initiation.
  • Pregnancy.
  • Association with cyclosporine A and glibenclamide.

http://www.drugs.com/mtm/bosentan.html