Atrial fibrillation (AF)

Diagnostic and therapeutic approach




150mg i.v. in 10 min, repeat 150 mg every 10-15 min up to a maximal dose of 500mg


1mg/min i.v.c. for 6h, then 0.5mg/min i.v.c. for 18h, max 2.2g/24h.


  • Known hypersensitivity against amiodarone or iodine.
  • Sinus bradycardia and sinoatrial block.
  • Severe disorders of high degree conduction.
  • Sick sinus syndrome.
  • Thyroid disorders (hypo- or hyperthyroidism).
  • Combination therapy with drugs that can cause "torsades de pointes".
  • Preexisting QT Prolongation.
  • Pregnancy and breast feeding.
  • Hypokalemia.
  • Combination therapy with MAOIs.