Atrial fibrillation (AF)

Diagnostic and therapeutic approach

  1. Diagnosis
  2. Treatment
  3. Scores
  4. Pharmaceuticals
  5. ESC recommandations

Pharmaceuticals

  1. Amiodarone
  2. Oral anticoagulants
  3. ß-Blockers
  4. Dabigatran (Pradaxa)
  5. Digitalis (Digoxine)
  6. Diltiazem (Dilzem)
  7. Dronedarone (Multaq)
  8. Flecainide (Tambocor)
  9. Ibutilide (Corvert)
  10. Propafenone (Rytmonorm)
  11. Rivaroxaban (Xarelto)
  12. Sotalol (Sotalex)
  13. Verapamil (Isoptin)
  14. Vernakalant (Brinavess)
  15. Apixaban (Eliquis)
  16. Edoxaban (Lixiana)

Amiodarone

(Cordarone)

Bolus

150mg i.v. in 10 min, repeat 150 mg every 10-15 min up to a maximal dose of 500mg

Maintenance

1mg/min i.v.c. for 6h, then 0.5mg/min i.v.c. for 18h, max 2.2g/24h.

Contra-indications

  • Known hypersensitivity against amiodarone or iodine.
  • Sinus bradycardia and sinoatrial block.
  • Severe disorders of high degree conduction.
  • Sick sinus syndrome.
  • Thyroid disorders (hypo- or hyperthyroidism).
  • Combination therapy with drugs that can cause "torsades de pointes".
  • Preexisting QT Prolongation.
  • Pregnancy and breast feeding.
  • Hypokalemia.
  • Combination therapy with MAOIs.

http://www.drugs.com/amiodarone.html