Pulmonary embolism (PE)

Diagnostic and therapeutic approach

4400 IU/kg in 10 minutes followed by 4400 IU/kg/h in 12 or 24h.

Known hypersensitivity to the active substances or to any of the excipients
Uncontrollable active bleeding, overt or occurred during the last 6 months
Known bleeding diathesis
Patients on oral anticoagulants
Head injury during the last 3 months
Surgery intracranial or spinal or other CNS disease such as intracranial neoplasia
Arteriovenous malformation or aneurysm
History or suspicion of cerebral hemorrhage, subarachnoid hemorrhage or suspected subarachnoid hemorrhage
Severe uncontrolled hypertension
Major surgical procedure or trauma during the last 10 days (including any trauma to the present myocardial)
Recent traumatic external heart massage (back within 10 days)
Childbirth and recent puncture of a non-compressible vessel (eg of the subclavian vein or jugular.)
Severe hepatic impairment, including liver failure
Cirrhosis
Portal hypertension (oesophageal varices) and active hepatitis
Bacterial endocarditis
Pericarditis
Acute Pancreatitis
Attacks ulcerative gastrointestinal documented over the last 3 months
Arterial aneurysm
Abnormalities arterial / venous
Neoplasms with increased risk of bleeding