Pulmonary embolism (PE)

Diagnostic and therapeutic approach

RtPA (Actilyse)



100mg of 2 hours or 0.6mg / kg over 15 minutes (maximum dose 50mg)


  • 10 mg i.v. bolus in 1 to 2 minutes
  • 90 mg i.v. infusion in 2 hours

The total dose of 1.5 mg / kg should not be exceeded in patients less than 65 kg.

Absolute contra-indications absolues

  • Known hypersensitivity to the active substances alteplase, gentamicin or any of the excipients
  • Uncontrollable active bleeding, overt or occurred during the last 6 months
  • Known bleeding diathesis
  • Patients on oral anticoagulants
  • Head injury during the last 3 months
  • Surgery intracranial or spinal or other CNS disease such as intracranial neoplasm, arteriovenous malformation, or aneurysm
  • History or suspicion of cerebral hemorrhage
  • Subarachnoid hemorrhage or suspected subarachnoid hemorrhage
  • Severe uncontrolled hypertension
  • Major surgical procedure or trauma during the last 10 days (including any trauma to the present myocardial)
  • Recent traumatic external heart massage (back within 10 days)
  • Childbirth and recent puncture of a non-compressible vessel (eg of the subclavian vein or jugular.)
  • Severe hepatic impairment, including liver failure
  • Cirrhosis
  • Portal hypertension (oesophageal varices) and active hepatitis
  • Bacterial endocarditis
  • Pericarditis
  • Acute Pancreatitis
  • Attacks ulcerative gastrointestinal documented over the last 3 months
  • Arterial aneurysm
  • Abnormalities arterial / venous
  • Neoplasms with increased risk of bleeding