Sacubitril + Valsartan (Entresto)

50 mg 2/d initially and then 100 mg or 200 mg 2 / d


  • Hypersensitivity to the active principles, sacubitril or valsartan, or to any excipients.
  • Concomitant use of an ACE inhibitor.
  • Entresto can be administered earlier than 36 hours after stopping treatment with ACE inhibitor.
  • Known antecedent of angioedema related to previous treatment with ACE inhibitor or ARB.
  • Concomitant use of Entresto with medicines containing aliskiren in patients with renal or diabetic impairment (GFR <60 ml / min / 1.73 m2).
  • Severe renal insufficiency with eGFR <10 ml / min / 1.73 m2 due to missing data.
  • Pregnancy.