Ivabradine (Procoralan)

Ivabradine can be consider on top of conventional treatment with ß-blockers if target heart rate is not reach (< 70 bpm).


  • Hypersensitivity to ivabradine.
  • Rest heart rate < 70 bpm.
  • Cardiogenic shock.
  • Acute MI.
  • Severe hypotension.
  • Severe liver disease.
  • Sick sinus syndrome.
  • Bloc sino-auriculaire ou atrio-ventriculaire du 3ème degré.
  • Association with cytochrome P450 3A4 inhibitors.
  • Association with diltiazem and verapamil.
  • Pregnancy.